To clarify the interrelationship between gastrin and somatcstatin, concentration of gastrin and somatostatin in blood and antral or duodenal mucosa of rats treated with cysteamine and/or indomethacin was measured, using radioimmunoassay kits.
The results were as follows;
1. The pH of gastric juice was significantly lower (p<0.005), serum, antral and duodenal gastrin concentration was significantly higher(p<0. 005), and plasma, antral and duodenal somatostatin concentration was significantly lower in rats treated with cysteamine.
2. The pH of gastric juice was significantly lower(p<0. 005), serum and duodenal gastrin concentration was significantly hi.-he:-(p<0. 005), and plasma, antral and duodenal somatostatin concentration was significantly lo*wer(p`0. 005) in rats treated with indomethacin.
3. The tendency to increase the change of gastrin and somatostatin corcentration in blood and tissues was noted in rats treated with cysteamine and indomethacin simultaneously.
4. In all experimental rats, there was
a. the inverse relationship between gastrin and somatostatin concentration in blood and duodenal mucosa.
b. the negative linear relationship between pH of gastric juice and serum gastrin concentration, and between pH of
gastric juice and antral gastrin.
c, the rositive linear relationship between pH of gastric juice and plasma so::matostation concentration, and between pH cf gastric juice and antral somatostatin concentration.
d. he positive linear relationship between serum and antral gastrin, between plasma and antral
somatostatin concentration, and bet; een plasma and duodenal somatostatin concentration.
It was suggested that cysteamine and indcmethacin influence on gastrin and somatostatin concentration in blood and mucosa, and there is the functional interrelationship lenveen acid secretion, gastrin and somatostatin concentration in blood and tissues.
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